Evaluation of Influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and Cold-Adapted Recombinant Viruses in Seronegative Adult Volunteers
Identifieur interne : 002780 ( Main/Exploration ); précédent : 002779; suivant : 002781Evaluation of Influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and Cold-Adapted Recombinant Viruses in Seronegative Adult Volunteers
Auteurs : Brian R. Murphy [États-Unis] ; Margret B. Rennels [États-Unis] ; R. Gordon Douglas [États-Unis] ; Robert F. Betts [États-Unis] ; Robert B. Couch [États-Unis] ; Thomas R. Cate [États-Unis] ; Robert M. Chanock [États-Unis] ; Alan P. Kendal [États-Unis] ; Hunien F. Maassab [États-Unis] ; Surapol Suwanagool [États-Unis] ; Steven B. Sotman [États-Unis] ; Luis A. Cisneros [États-Unis] ; William C. Anthony [États-Unis] ; David R. Nalin [États-Unis] ; Myron M. Levine [États-Unis]Source :
- Infection and Immunity [ 0019-9567 ] ; 1980.
Abstract
Two attenuated influenza A donor viruses, the A/Udorn/72
Url:
PubMed: 7216417
PubMed Central: 551124
Affiliations:
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Le document en format XML
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-1A2 and Cold-Adapted Recombinant Viruses in Seronegative Adult Volunteers</title>
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<author><name sortKey="Betts, Robert F" sort="Betts, Robert F" uniqKey="Betts R" first="Robert F." last="Betts">Robert F. Betts</name>
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<author><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name>
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<author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name>
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<author><name sortKey="Maassab, Hunien F" sort="Maassab, Hunien F" uniqKey="Maassab H" first="Hunien F." last="Maassab">Hunien F. Maassab</name>
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<author><name sortKey="Suwanagool, Surapol" sort="Suwanagool, Surapol" uniqKey="Suwanagool S" first="Surapol" last="Suwanagool">Surapol Suwanagool</name>
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<author><name sortKey="Sotman, Steven B" sort="Sotman, Steven B" uniqKey="Sotman S" first="Steven B." last="Sotman">Steven B. Sotman</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Influenza A/Hong Kong/123/77 (H1N1) <italic>ts</italic>
-1A2 and Cold-Adapted Recombinant Viruses in Seronegative Adult Volunteers</title>
<author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name>
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<author><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name>
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</placeName>
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</affiliation>
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<author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name>
<affiliation wicri:level="2"><nlm:aff id="af5">Center for Disease Control, Atlanta, Georgia 30333</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Center for Disease Control, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maassab, Hunien F" sort="Maassab, Hunien F" uniqKey="Maassab H" first="Hunien F." last="Maassab">Hunien F. Maassab</name>
<affiliation wicri:level="2"><nlm:aff id="af6">Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, Michigan 43104</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suwanagool, Surapol" sort="Suwanagool, Surapol" uniqKey="Suwanagool S" first="Surapol" last="Suwanagool">Surapol Suwanagool</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sotman, Steven B" sort="Sotman, Steven B" uniqKey="Sotman S" first="Steven B." last="Sotman">Steven B. Sotman</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cisneros, Luis A" sort="Cisneros, Luis A" uniqKey="Cisneros L" first="Luis A." last="Cisneros">Luis A. Cisneros</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Anthony, William C" sort="Anthony, William C" uniqKey="Anthony W" first="William C." last="Anthony">William C. Anthony</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nalin, David R" sort="Nalin, David R" uniqKey="Nalin D" first="David R." last="Nalin">David R. Nalin</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name>
<affiliation wicri:level="2"><nlm:aff id="af2">Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Vaccine Development, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
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<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="1980">1980</date>
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<front><div type="abstract" xml:lang="en"><p>Two attenuated influenza A donor viruses, the A/Udorn/72 <italic>ts</italic>
-1A2 and the A/Ann Arbor/6/60 cold-adapted (<italic>ca</italic>
) viruses, are being evaluated for their ability to reproducibly attenuate each new variant of influenza A virus to a specific and desired level by the transfer of one or more attenuating genes. Each of these donor viruses has been able to attenuate influenza A viruses belonging to the H3N2 subtype by the transfer of one or more attenuating genes. To determine whether these two donor viruses could attenuate a wild-type virus that belonged to a different influenza A subtype, <italic>ts</italic>
-1A2 and <italic>ca</italic>
recombinants of a wild-type virus representative of the A/USSR/77 (H1N1) Russian influenza strain were prepared and evaluated in adult doubly seronegative volunteers at several doses. The recombinants derived from both donor viruses were attenuated for the doubly seronegative adults. Less than 5% of infected vaccinees developed a febrile or systemic reaction, whereas five of six recipients of wild-type virus developed such a response. The 50% human infectious dose (HID<sub>50</sub>
) for each recombinant was approximately 10<sup>5.0</sup>
50% tissue culture infective doses. The virus shed by the <italic>ts</italic>
-1A2 and <italic>ca</italic>
vaccinees retained the <italic>ts</italic>
or <italic>ca</italic>
phenotype, or both. This occurred despite replication of the recombinant viruses for up to 9 days. No evidence for transmission of the <italic>ca</italic>
or <italic>ts</italic>
-1A2 recombinant virus to controls was observed. A serum hemagglutination inhibition response was detected in less than 50% of the infected vaccinees. However, with the more sensitive enzyme-linked immunosorbent assay, a serological response was detected in 100% of the <italic>ca</italic>
vaccinees given 300 HID<sub>50</sub>
and approximately 70% of <italic>ca</italic>
or <italic>ts</italic>
vaccinees who received 10 to 32 HID<sub>50</sub>
of virus. These results indicate that the recombinants derived from both donor viruses were satisfactorily attenuated and were stable genetically after replication in doubly seronegative adults although they induced a lower serum hemagglutination inhibition response than that found previously for H3N2 <italic>ts</italic>
and <italic>ca</italic>
recombinants.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
<li>Maryland</li>
<li>Michigan</li>
<li>Texas</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name>
</region>
<name sortKey="Anthony, William C" sort="Anthony, William C" uniqKey="Anthony W" first="William C." last="Anthony">William C. Anthony</name>
<name sortKey="Betts, Robert F" sort="Betts, Robert F" uniqKey="Betts R" first="Robert F." last="Betts">Robert F. Betts</name>
<name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name>
<name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name>
<name sortKey="Cisneros, Luis A" sort="Cisneros, Luis A" uniqKey="Cisneros L" first="Luis A." last="Cisneros">Luis A. Cisneros</name>
<name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name>
<name sortKey="Douglas, R Gordon" sort="Douglas, R Gordon" uniqKey="Douglas R" first="R. Gordon" last="Douglas">R. Gordon Douglas</name>
<name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name>
<name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name>
<name sortKey="Maassab, Hunien F" sort="Maassab, Hunien F" uniqKey="Maassab H" first="Hunien F." last="Maassab">Hunien F. Maassab</name>
<name sortKey="Nalin, David R" sort="Nalin, David R" uniqKey="Nalin D" first="David R." last="Nalin">David R. Nalin</name>
<name sortKey="Rennels, Margret B" sort="Rennels, Margret B" uniqKey="Rennels M" first="Margret B." last="Rennels">Margret B. Rennels</name>
<name sortKey="Sotman, Steven B" sort="Sotman, Steven B" uniqKey="Sotman S" first="Steven B." last="Sotman">Steven B. Sotman</name>
<name sortKey="Suwanagool, Surapol" sort="Suwanagool, Surapol" uniqKey="Suwanagool S" first="Surapol" last="Suwanagool">Surapol Suwanagool</name>
</country>
</tree>
</affiliations>
</record>
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